BEMÆRK: Ansøgningsfristen er overskredet
Postdoc in Bioinformatics: Structural variations associated to circular DNA in cancer
Department of Biology
Faculty of Science
University of Copenhagen
Department of Biology, Faculty of Science at University of Copenhagen is offering a position in bioinformatics for a postdoc for the analysis of extrachromosomal circular DNA.
Job description – circular DNA as a marker for cancer
Extrachromosomal DNA circles are known from tumors where they carry proto-oncogenes and can induce tumorigenesis (DOI: 10.1016/j.tig.2022.02.007). Our recent data reveal that circular DNA is also found in blood plasma as circular circulating tumor DNA (circular ctDNA), suggesting that this new type of ctDNA can be an efficient marker for cancer. We now aim to find patterns of the circular DNA in blood plasma and tumors from our thousands of samples that can serve as markers for cancer, relapse and prognosis of cancer. We will put emphasis on applying and developing cutting-edge bioinformatics methods for identification of patterns in circular DNA and novel structural circular DNA variants. The development of the methods for will include clustering and machine learning methods with output allowing for biological interpretations of the roles of circular DNA in cancer.
Description of the scientific environment You will be member of the Regenberg and Gorodkin research teams (Regenberg Lab; Computational Biology and Bioinformatics group). We explore the biology of circular DNA in eukaryotic systems taking advantage of our highly sensitive methods for detection and analysis of circular DNA in yeast, animals, and human cancer from whole genome data. You will be working in close contact with other scientists in bioinformatics, and experimentalists that purify, sequence and analyze the circular DNA in thousands of plasma and tumors of cancer patients. We offer an exciting international work environment in our renowned teams with ample opportunity to develop a strong scientific career. The project will be carried out at the Section for Ecology and Evolution, Department of Biology and with Professor Jan Gorodkin, Computational Biology and Bioinformatics group at Department of Veterinary and animal Sciences, University of Copenhagen.
Supervisors are associate Professor, Birgitte Regenberg, Department of Biology, bregenberg@bio.ku.dk, direct phone: +4535321680, and Professor Jan Gorodkin, gorodkin@sund.ku.dk, Direct Phone: +4523375667. https://www.regenberglab.net/; https://www1.bio.ku.dk/english/research/ecology-evolution/staff/?pure=en/persons/23899
The position is available for a 24-month period (postdocs) and your key task is to manage and carry through your research project.
Formal requirements
Applicants should hold a PhD degree in Bioinformatics or a similar discipline must be familiar with the Linux environment and have expertise in programming (mainly R and Python). Fluency in spoken and written English is a requirement. As criteria for the assessment of your qualifications emphasis will also be laid on previous publications (if any) and relevant work experience.
Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.
Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.
Negotiation for salary supplement is possible.
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Please include
- Curriculum vitae
- Diplomas (Master and PhD degree or equivalent)
- Research plan – description of current and future research plans
- Complete publication list
- Separate reprints of 3 particularly relevant papers
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.
Interviews will be held during week 28.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Frederiksberg Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
KU - SCIENCE - BIO, Universitetsparken 13, August Krog Byg., 2100 København Ø
-Ansøgning:
Ansøgningsfrist: 21-06-2023; - ansøgningsfristen er overskredet
Ved skriftlig henvendelse: https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=159450&DepartmentId=18965&MediaId=4632&SkipAdvertisement=true
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5848997